普瑞巴林USP RC A
4-Isobutyl-2-pyrrolidinone (pregabalin lactam impurity)
CAS: 61312-87-6
Molecular Formula: C8H15NO
普瑞巴林USP RC A - Names and Identifiers
普瑞巴林USP RC A - Physico-chemical Properties
| Molecular Formula | C8H15NO |
| Molar Mass | 141.21 |
| Density | 0.927±0.06 g/cm3(Predicted) |
| Boling Point | 269.1±9.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Colourless to Light Yellow Oil to Low-Melting |
| pKa | 16.66±0.40(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
普瑞巴林USP RC A - Risk and Safety
| HS Code | 2933790002 |
| Hazard Class | IRRITANT |
普瑞巴林USP RC A - Reference Information
| Use | The lactam compound 4-isobutyl-2-pyrrolidone is a key intermediate in the synthesis of pregabalin, can be used in the laboratory chemical medicine research and development process. |
| preparation | in 600 of methanol, 50.00G of nitro compound (01) and 18.04G of NiCl2 · 6H2O were added; the solution was cooled to 0-5 °c and 18.2g of sodium borohydride was added. After the addition, the temperature was raised to 40 ° C. To 45 ° C. And the mixture was stirred for 12 hours. Then, the mixture was cooled to room temperature, and hydrochloric acid aqueous solution was added dropwise to adjust pH = 2-3. The reaction solution was concentrated under reduced pressure until the system had no obvious methanol (detected by gas chromatography), and was extracted with ethyl acetate, washed with water, the organic layer was dried and concentrated to obtain lactam compound (02). Isobutyl-2-pyrrolidone, light yellow oil 31.20G, yield 96.0%, purity 99.10%. |
Last Update：2024-04-10 22:29:15
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